Retatrutide GCGR Signaling and Hepatic Lipid Metabolism: Research Mechanisms and Study Limitations
Research Overview Retatrutide, also designated LY3437943, is a synthetic peptide compound designed to engage three receptor targets simultaneously: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR). Each receptor has a distinct pharmacological profile, and the GCGR component has drawn serious attention from hepatology researchers because of what…